No person, no matter where in an organizational hierarchy, has all the knowledge needed to thrive in the network era. Neither does any company. Neither does any government. We are all connected and dependent on each other. Hierarchies divide us.

Managing professional relationships as a network allows each node (person) to be unique. This removes the artificial barrier of the job, which assumes that people are replaceable, and that knowledge flows up and down. Knowledge in a network is about connecting experiences, relationships, and situations.

How else will London change?
There will be a prodigious number of old people. One area which is going to grow is gerontology and problems of old age. The average life expectancy in London has gone up 18 months since I was elected, people are living longer and longer and there is a huge medical opportunity there. I think what the prime minister has done about setting up a special institute for dementia, that’s the right approach and London should be at the forefront of trying to tackle that range of diseases.

There are certainly numerous neurotransmitter systems in the brain that have not yet been exploited pharmacologically and may yet prove to be important in the pathogenesis of depression. Interestingly, one of these is the glutamate system. Recent research appears to have shown that low concentrations of the glutamate receptor blocker ketamine may produce an antidepressant effect that is unusually rapid. However, the price of developing new drugs is becoming more and more expensive, leading to a possible scenario in which large pharmaceutical companies actually cease doing groundbreaking preclinical research in psychopharmacology and leave this task to others, their role reduced to developing and marketing promising new compounds discovered elsewhere

Excerpt From: Miller, Richard J. “Drugged.” Oxford University Press, USA, 2014

The harder road, trickier, and more sustainable, is to make shifts every day within our existing reality. To integrate, not obliterate. For Sheryl Sandberg, Lean In was a tiny yet growing piece of her heart for years until it exploded into the world — all the while she was still running one of the world’s biggest companies and raising two children. Weaving our Must into our existing reality is about co-designing small opportunities with our teams. It’s about setting aside quiet time to be alone with our thoughts, and then actually following through. It’s about doing one small thing, anything, to honor our personal truth — today.

Perhaps the most interesting facet of the book is Miller’s demonstration that the progress of understanding in this field has been very far from the smoothly efficient hypothesis-driven caricature of science that is often promoted by its own defenders. For a start, most of the important therapeutic drugs of the 20th century were discovered by accident, and some in surprising places. Antipsychotics were developed from substances produced during the search for fashionable clothes dyes in the 19th century; while antidepressants came out of research that sought novel compounds deriving from a glut of leftover rocket fuel from the Nazis’ V2 programme.

Only after the beneficial effects of such substances were serendipitously noticed by scientists did they then try to figure out why they worked. Miller’s explanations of these investigations make for excellent intellectual detective stories, as much for naturally produced drugs as synthetic ones. Why should the human brain, for example, have “receptors” that spark hungrily in the presence of nicotine or opiates? It was not, as it turned out, that God intended us to smoke our heads off, but that these vegetable substances mimicked what were subsequently discovered to be the brain’s own signalling chemicals – neurotransmitters. (Miller doesn’t address the further interesting question as to why the poppy or tobacco plant should produce substances that trick our receptors in the first place. Happy accident – or brilliant evolutionary strategy for getting themselves widely cultivated?) Thus, research on drugs has contributed enormously to our understanding of the brain.

Let’s say someone in the design house is working on a project for Burberry, the clothing brand. They go to the basement and pour off a pint size container called “the latest thing in luxury clothing.” Someone working for the ad agency is looking for information on the way housewives think about breakfast. The pipe provides here too. The book review man for Monocle, is always on the look out for new books but for that great cloud of ideas and sentiments that make our culture now.

It sounds a little complicated, but there is a big idea here. In fact, Monocle has found a way to maximize its return on investment. What flows in from that pipe is used 5 times, as design, advertising, strategy, print on the page and words in the air. Everything it learns, it turns to advantage. If the print client doesn’t want something, the strategy client will. And sometimes, a single understanding of the world pays off in all 5 of the Monocle faces. And that, ladies and gentlemen, is what you call a robust ROI.

And this is no simple “pass through” model. Monocle accelerates what it learns. Inevitably, the people designing for Burberry end up talking to the ad people. The ad people reply with their latest learnings. And everyone listens to Dan, the book reviewer, because he knows what’s happening in the world of arts, letters and ideas.